Clinical Research in The Residency Period at a Glance: A Survey in
The University
text
article
2020
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Background: Evidence Based Medicine (EBM) training in residency program not only facilitates development of skills needs to practice of medicine but also helps learning of research principles involve publishing evidence. In this study, we aim to clarify the research barriers which residents in Kerman University of Medical Sciences may face in our health care setting and to determine factors influencing their research activities.Methods: This is a descriptive cross sectional study. The study sample consisted of 140 medical residents of all fields of the University. Data were collected by a reliable and valid administered questionnaire related to 5 obstacle in research including educational, Personal and professional, Resources and their management.Results: Three types of obstacles were considered to affect research activities by most of the respondents, with maximum agreement identifying educational obstacles in research skills development. Personal and professional, Resources and their management were included two the other type of obstacles. There were no significant differences by field of study, and durations of their course in these issues.Conclusion: All residents in all grade of education emphasized similar factors influenced their research activities, the most important of which was their research skills such as literature review and scientific writing. Therefore, our findings show that the student specialists can conduct scientific and effective research in their course provided that we can design research training courses to develop staff and their trainees in our university.
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
1
10
https://ajcr.kmu.ac.ir/article_91649_6d8311dec525d787ad35e40696303d80.pdf
dx.doi.org/10.22122/ajcr.2020.91649
Evaluation of serum level of interleukin 17 in patients with ischemic
heart disease referring to Afzalipour hospital in Kerman
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article
2020
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Background: Ischemic heart disease (IHD) is a cardiovascular disease, in which inflammation plays a key role. The immune cells (white blood cells) and interleukins play a very important role in inflammation and the invasion and migration of leukocytes to the site of inflammation. The aim of this study was to evaluate the serum level of interleukin 17 in patients with IHD and its relationship with the risk factors for the disease.Methods: A total of 300 patients with IHD were included in this study. The patients were divided into three equal groups, namely, acute myocardial infarction (AMI), stable angina (SA), and unstable angina (UA). Also, one group was considered as the control group. Serum levels of interleukin 17 were measured by ELISA kit, according to the manufacturer's instructions.Results: Serum levels of IL-17 in the AMI, SA, UA, and control groups were 6.08 ± 1.12, 5.81 ± 1.05, 7.11 ± 1.37, and 3.46 ± 0.90, respectively. Statistical analysis showed that the difference between different groups of patients and the control group was significant (P<0.01). There was no significant differences in the serum level of interleukin 17 between different groups of patients (P>0.05). The sSerum levels of interleukin 17 in diabetic patients were significantly higher than those in non-diabetic patients (P<0.03).Conclusion: The results showed that the serum levels of interleukin 17 were associated with ischemic heart disease, and mechanisms related to interleukin 17 were associated with IHD. Interleukin 17 is an inflammatory interleukin, which is associated with increased inflammation in the pathogenesis of IHD. Diabetes mellitus may increase inflammatory factors, such as interleukin 17, like pre-inflammatory interleukins, therefore, it is associated with the pathogenesis of IHD.
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
11
20
https://ajcr.kmu.ac.ir/article_91650_cd6d3f7c3dfd1689896185a726cfb1c6.pdf
dx.doi.org/10.22122/ajcr.2021.91650
Survey of Epidemiology and Molecular Identification of
Cutaneous Leishmaniasis in Marvdasht County, Fars Province
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article
2020
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Background: Leishmaniasis is one of the zoonosis diseases between humans and livestock that is caused by different species of protozoan of Leishmania genus and, due to its species and host immune response, produces various clinical forms. The aim of this study was to determine the molecular diagnosis of cutaneous leishmaniasis in Marvdasht city.Methods: This descriptive cross-sectional study was conducted on 333 suspected cases of cutaneous leishmaniasis referring to the health network of Marvdasht city. After the smear was prepared from the patient's lesion and Gimsa staining, the parasite amastigotes were observed using a light microscope. Polymerase chain reaction (PCR) was performed using specific primers LIN4 and LIN17 to amplify the KDNA gene.Results: Leishmania parasites were confirmed by microscopic and molecular methods in 133 samples. The PCR results showed that the causative agent in all 133 samples was leishmania major. By analyzing Patients' demographic data and spatial distribution revealed that the occurrence of the disease in men (50/4%), summer (60/3%), September (29/3%), age group 27/26-44/50 (27/1%), housewives (24.8%) and rural (53/4%) were more than other groups. The hands (38/3%) were the most affected. Most patients (50%) had a lesion in their limbs.Conclusion: The cutaneous leishmaniasis samples obtained in Marvdasht city are mainly rural leishmaniasis, that in this type, the reservoir of disease is wild rodents, especially rats. Therefore, in order to control and prevent this disease, the fight against rodents as one of the most important control strategies should be given priority
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
21
32
https://ajcr.kmu.ac.ir/article_91651_9f17bcae15f5b838d258815a74385684.pdf
dx.doi.org/10.22122/ajcr.2020.91651
Effectiveness of Cognitive Group-Therapy Based on Michael Free
on Mental Health in Patients with Multiple Sclerosis
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article
2020
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Background: In addition to physical characteristics, patients with chronic illnesses are in trouble with psychological characteristics, also. This study aimed to examine the effect of the Effectiveness of Cognitive Group-Therapy Based on Michael Free on mental health in patients with Multiple Sclerosis.Methods: The population was all the patients with MS in Hamedan. In a semi-experimental design and using convenience sampling, 30 participants were selected among those patients and they were divided in two groups of intervention and control by random. The former and latter clusters were trained in between the one and one and half an hour of 6 sessions while the control group had no therapeutic training. The therapeutic clusters were assessed with Lovibond depression, anxiety; stress (DASS, 1995) were completed at three stages; prior to, four weeks later, and two months after the intervening sessions. Data were subjected to descriptive statistics and analysis with MANOVA.Results: The results of this study showed that there were significant differences between test and control groups after intervention (P < 0.001). In fact, scores of depression, anxiety, and stress in the experimental group were significantly reduced after treatment. This effect was also a visible follow-up period.Conclusion: According to the results above, we can say, in the area of treatment and working on patients with Multiple Sclerosis cognitive group therapy seems to be very efficient and useful. So, in addition to medical interventions for patients with multiple sclerosis that is done, there is a need for psychological interventions.
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
33
44
https://ajcr.kmu.ac.ir/article_91653_2d4fb151b6de56d19e047d6eac3a5f9d.pdf
dx.doi.org/10.22122/ajcr.2020.91653
Evaluation of deletion duplication mutation of p53 gene in gastric
cancer patients in Kerman city by MLPA technique
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article
2020
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Abstract Background: Gastric cancer (GC) is a heterogeneous disease driven by multiple genetic and epigenetic aberrations. Tp53 gene is commonly mutated in GC and correlation ofp53 mutation with clinicopathological features is contraversial. The aim of this study was firstly detection of deletion/duplication mutations in T P53 exones using multiplex ligation-dependent probe amplification (MLPA) method in GC patients and, Secondly, we investigated p53 mutation relationship with GC clinicopatholoic features. Methods: 60 GC patients were enrolled in this study and all 11 Tp53 gene exones were assessed by MLPA method. Results: most mutation was occurred in exon 1.p53 mutation was found most frequently in GC with lymph node metastasis (p:0.032) and differentiated GC (P:0.04) . Conclusion: Regarding most mutations were located in exon 1,this exone may play important role in GC carcinogenesis. More common p53 mutation in GC with lymph node metastasis indicates GC with p53 mutation may need intensive adjuvant chemotherapy or frequent follow up to prevent relapse.
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
45
55
https://ajcr.kmu.ac.ir/article_91682_6b7e0d49e8b796b716367b450d846961.pdf
dx.doi.org/10.22122/ajcr.2020.91682
Remyelination therapies: A promising and modern therapeutic
approach to the treatment of multiple sclerosis
text
article
2020
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Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS) in which Myelin sheath and oligodendrocyte in a process called demyelination are destroyed. In the onset of disease, a spontaneous repair procedure launches in which new myelin sheaths are elaborated and remyelination happens.Methods: This review study was carried out in 2020. Articles on the related topic were explored in the Internal and external databases. A total of 235 related research papers, in English and Persian since 2000 were extracted under the keywords “remyelination and multiple sclerosis” and on the basis of relevance 70 were included. Articles with unknown sample size and methodology or with no full text access were excluded.Results: The currently available medications for multiple sclerosis are mostly immunemodulating and do not directly improve repair. White matter regeneration, is a new and potential approach to treating multiple sclerosis, as remyelination repairs the damaged regions of the central nervous system.Conclusion: For the majority of MS patients, recovery process fails and oligodendrocyte are not able to regenerate the demyelinated axons. Axons are destroyed and symptoms commence. Therefore, early modulations to preserve oligodendrocytes and induce remyelination could be a promising therapeutic goal in treatment of MS. In this review, we explore several effective therapies and clinical trials for the recovery of the lost myelin.
Afzalipour Journal of Clinical Research
Vesnu Publications
2588-4174
5
v.
1
no.
2020
56
69
https://ajcr.kmu.ac.ir/article_91804_97ceaf396bbbcd1493ddeb807ff2102d.pdf
dx.doi.org/10.22122/ajcr.2020.91804