عنوان مقاله [English]
Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the
central nervous system (CNS) in which Myelin sheath and oligodendrocyte in a process called
demyelination are destroyed. In the onset of disease, a spontaneous repair procedure launches in
which new myelin sheaths are elaborated and remyelination happens.
Methods: This review study was carried out in 2020. Articles on the related topic were explored
in the Internal and external databases. A total of 235 related research papers, in English and
Persian since 2000 were extracted under the keywords “remyelination and multiple sclerosis”
and on the basis of relevance 70 were included. Articles with unknown sample size and
methodology or with no full text access were excluded.
Results: The currently available medications for multiple sclerosis are mostly immunemodulating and do not directly improve repair. White matter regeneration, is a new and potential
approach to treating multiple sclerosis, as remyelination repairs the damaged regions of the
central nervous system.
Conclusion: For the majority of MS patients, recovery process fails and oligodendrocyte are not
able to regenerate the demyelinated axons. Axons are destroyed and symptoms commence.
Therefore, early modulations to preserve oligodendrocytes and induce remyelination could be a
promising therapeutic goal in treatment of MS. In this review, we explore several effective
therapies and clinical trials for the recovery of the lost myelin.